Keybreeze

This is a really useful program.
A very lightweight command line sits in your system tray and can be recalled by a hotkey to type customized shortcuts to possibly everything you want to launch on your computer. Actually you usually just have to type the first two letters of the file, the program or the site and you'll see it highlighted in a pop up list above the line, all you have to do is press enter.
The default hotkey to activate Keybreeze is the semicolon. That might be a bit annoying when typing in a document, because you have to press Enter as well to actually insert a semicolon in a document. You better modify the hotkey to a combination which is unique and can be easily recalled. Mine is Ctrl + <
I shouldn't explain much about this program, because both the site and the program tutorial are quite exhaustive, you should follow the whole tutorial to use the full potential of this program, which is simple for a basic use, but has many features you wouldn't even imagine.
A right click option is added to the right-click menu of any icons of your PC, which allows to set shortcuts even faster than through the command list.
Before using Keybreeze to launch sites, I advice to check the box to open them in the same browser window, in the options. The sites will be opened in new tabs of your browser, and not in new windows.
Keybreeze can be used (carefully) for system commands as well. It comes loaded with preset shortcuts, for example start typing "close" and you'll see "close window" in the command list.
Another really interesting feature are the letter commands, you type a certain letter and ":" before the term and this gives you access to a lot of functions: "s:" to search the web on Google, "w:" for Wikipedia, "d:" for Dictionary.com etc.
If all these features weren't enough you can still record your macros, sequences of keys or mouse movements, but you won't usually need them.
Keybreeze can be used to insert text with shortcuts as well.
It has been designed to use a minimal amount of resources, the command line appears only when you start typing the shortcut after having recalled it through the hotkey.
Keybreeze will probably remind to the most experienced users when most funcions on DOS and early Windows were recalled through the command line, but the simplifying features here are endless, it's amazing how a program like this can change the way you use your computer, I strongly recommend it.